Peptide handling
Semaglutide reconstitution calculator
Reconstitution calculator for Semaglutide, prefilled for 2 mg and 5 mg and 10 mg vials. Work out the concentration, the dose volume in millilitres, and the reading on a U-100 insulin syringe.
Start from a compound
Fills the vial size and a starting water volume. Only compounds with a citable range fill a dose.
The second is the question asked once the syringe is already filled, or when checking a vial someone else reconstituted.
1 mg = 1,000 mcg. Published figures are usually micrograms; vial labels are milligrams.
- Draw to
- 25 unitson a U-100 syringe
- Dose
- 250 mcg
- Dose volume
- 0.25 mL
- Concentration
- 1 mg/mL
- Per unit
- 10 mcg
- Doses per vial
- 8whole doses; a partial one is not counted
Shown on a 30-unit (0.3 mL) U-100 syringe, the smallest that holds this draw.
Semaglutide — Approved label or registrational trial
Taken from an approved label or the trial it was based on. The prefilled dose is the low end of that range, weekly, escalated in steps over months.
Vial size and water volume are a starting point for the arithmetic, not a recommendation.
Adding more water makes the same dose a larger, easier-to-read mark on the syringe. It does not change how many doses the vial holds.
Vial sizes and starting volume
Semaglutide is commonly supplied in 2 mg and 5 mg and 10 mg vials. The calculator opens on a 2 mg vial with 2 mL of bacteriostatic water — a starting point for the arithmetic, not a recommendation. Change either and everything recalculates.
That combination gives 1 mg/mL, so one insulin unit holds 10 mcg and a 250 mcg dose is 25 units.
Half-life, and why it matters here
Approximately one week, which is why the approved schedule is weekly. A shorter half-life is why some protocols split a daily amount across more than one administration, which means more and smaller draws from the same vial — and a smaller draw is where a thinner dilution becomes harder to read accurately.
Approved label or registrational trial — Taken from an approved label or the trial it was based on.
The half-life and clearance calculator works this through for a given dose.
What dose to enter
A range of 250–2400 mcg per dose can be cited for Semaglutide, weekly, escalated in steps over months. The dose field opens at the low end of it.
Approved label or registrational trial
Taken from an approved label or the trial it was based on.
- FDA prescribing information — semaglutide injection — Approved product label. The escalation schedule and maximum are on the approved label. This is the only compound class here with a range of that provenance.
Related
- Semaglutide — the product page, with its current batch.
- Bacteriostatic water — what goes in the vial.
- Peptide reconstitution calculator — the general version, with the blend and half-life calculators alongside it.
- Dosing reference — published schedules, each with the evidence behind it.
For research use only. This tool performs arithmetic on figures you supply — it is not medical guidance and does not recommend a dose for any compound.